An ultrahigh-throughput screening assay for estrogen receptor ligands.

@article{Allan1999AnUS,
  title={An ultrahigh-throughput screening assay for estrogen receptor ligands.},
  author={George F. Allan and Alexander Hutchins and Joanna Clancy},
  journal={Analytical biochemistry},
  year={1999},
  volume={275 2},
  pages={
          243-7
        }
}
Members of the steroid and thyroid hormone receptor superfamily (nuclear receptors) play diverse roles in mammalian physiology, in both normal and pathological states. For this reason, and because nuclear receptors are natural receptors for lipophilic small molecules, they are important therapeutic targets for the pharmaceutical industry. Here we describe a method for screening for ligands for one of these receptors, the estrogen receptor. The method is rapid, robust, and reliable, and has been… CONTINUE READING
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