An ultra-low-input native ChIP-seq protocol for genome-wide profiling of rare cell populations.

@article{Brindamour2015AnUN,
  title={An ultra-low-input native ChIP-seq protocol for genome-wide profiling of rare cell populations.},
  author={Julie Brind'amour and Sheng Yi Liu and Matthew E. Hudson and Carol C L Chen and Mohammad M. Karimi and Matthew C. Lorincz},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={
          6033
        }
}
Combined chromatin immunoprecipitation and next-generation sequencing (ChIP-seq) has enabled genome-wide epigenetic profiling of numerous cell lines and tissue types. A major limitation of ChIP-seq, however, is the large number of cells required to generate high-quality data sets, precluding the study of rare cell populations. Here, we present an ultra-low-input micrococcal nuclease-based native ChIP (ULI-NChIP) and sequencing method to generate genome-wide histone mark profiles with high… CONTINUE READING
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