An oxysterol signalling pathway mediated by the nuclear receptor LXRα

@article{Janowski1996AnOS,
  title={An oxysterol signalling pathway mediated by the nuclear receptor LXR$\alpha$},
  author={B. A. Janowski and P. J. Willy and T. Devi and J. Falck and D. Mangelsdorf},
  journal={Nature},
  year={1996},
  volume={383},
  pages={728-731}
}
CHOLESTEROL and its oxysterol congeners are important constitu-ents of cell membranes and function as intermediates in several crucial biosynthetic pathways. These compounds autoregulate their metabolic fate by end-product repression and activation of downstream catabolism1. Although end-product repression by oxysterols is relatively well understood2, the mechanism by which these compounds act as positive transcription signalling molecules is unknown. Here we identify a specific group of… Expand
Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway*
  • J. Lehmann, Steven A. Kliewer, +8 authors T. Willson
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1997
Oxysterol signaling links cholesterol metabolism and inflammation via the liver X receptor in macrophages.
The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism.
Sterols and gene expression: control of affluence.
Regulation of the Pregnane X Receptor Signaling Pathway
Oxysterols and Their Cellular Effectors
Sterol Intermediates from Cholesterol Biosynthetic Pathway as Liver X Receptor Ligands*
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