An oxidatively-activated safety catch linker for solid phase synthesis.

@article{Davies2008AnOS,
  title={An oxidatively-activated safety catch linker for solid phase synthesis.},
  author={Stephen G Davies and Duncan Mortimer and Andrew W. Mulvaney and Angela J. Russell and Hjalmar Skarphedinsson and Andrew D Smith and Richard J. Vickers},
  journal={Organic & biomolecular chemistry},
  year={2008},
  volume={6 9},
  pages={
          1625-34
        }
}
A N-benzyl-4-amino-2,2-dimethylbutanoic acid-based system has been developed as a new oxidatively activated safety catch linker for reaction monitoring and optimisation on solid support. The CAN promoted oxidative debenzylation of the tertiary N-benzylamine moiety, followed by concomitant cyclisation and release of alcohols and amines has been demonstrated both in solution phase model studies and on the solid phase. The linker system has been applied to the solid phase synthesis of a collection… CONTINUE READING

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