An overview on the development of new potentially active camptothecin analogs against cancer.

@article{Chazin2014AnOO,
  title={An overview on the development of new potentially active camptothecin analogs against cancer.},
  author={Eliza de Lucas Chazin and Ra{\'i}sa da R. Reis and Walcimar Trindade Vellasco Junior and Lucas Fajardo Elmor Moor and Thatyana Rocha Alves Vasconcelos},
  journal={Mini reviews in medicinal chemistry},
  year={2014},
  volume={14 12},
  pages={
          953-62
        }
}
  • Eliza de Lucas Chazin, Raísa da R. Reis, +2 authors Thatyana Rocha Alves Vasconcelos
  • Published in
    Mini reviews in medicinal…
    2014
  • Chemistry, Medicine
  • Camptothecin (CPT) and its derivatives comprise an important group of heterocyclic compounds that are well recognized for their anticancer activities. Efforts have been made over the years aiming to develop new CPT analogs with better clinical efficacy, improved pharmacokinetic profile and lower toxicity. First generation of analogs, irinotecan (CPT-11) and topotecan (TPT) was approved for use by FDA in 1996 for the treatment of colorectal (CPT-11) and cervical, ovarian and small lung cancers… CONTINUE READING

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