An overview on 2-methyl-2,4-pentanediol in crystallization and in crystals of biological macromolecules.

Abstract

2-Methyl-2,4-pentanediol (MPD) is the most popular chemical additive used for crystallization of biological macromolecules. However, the mechanism of its action on proteins in aqueous solution is not well understood. We have carried out a systematic analysis of the conformation and environment of MPD molecules bound to proteins. We find that the majority of… (More)

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