An overview of the toxicology of HFA-134a (1,1,1,2-tetrafluoroethane)

@article{Alexander1995AnOO,
  title={An overview of the toxicology of HFA-134a (1,1,1,2-tetrafluoroethane)},
  author={D. J. Alexander and S. Libretto},
  journal={Human & Experimental Toxicology},
  year={1995},
  volume={14},
  pages={715 - 720}
}
1 This paper reviews the results of preclinical toxicology studies on HFA-134a carried out by Glaxo Research and Development Ltd. 2 A comprehensive range of studies was conducted in ani mal models suitable for the type of investigation. 3 The inhalation route of administration was used in all in vivo studies (with the exception of local tolerance and sensitisation studies) as patients will be exposed only to vapour during actuation of metered-dose inhalers. Cell cultures used for in vitro… Expand
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