An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants

@article{Dubey2007AnOO,
  title={An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants},
  author={V. Dubey and R. Bhalla and R. Luthra},
  journal={Journal of Biosciences},
  year={2007},
  volume={28},
  pages={637-646}
}
Terpenoids are known to have many important biological and physiological functions. Some of them are also known for their pharmaceutical significance. In the late nineties after the discovery of a novel non-mevalonate (non-MVA) pathway, the whole concept of terpenoid biosynthesis has changed. In higher plants, the conventional acetate-mevalonate (Ac-MVA) pathway operates mainly in the cytoplasm and mitochondria and synthesizes sterols, sesquiterpenes and ubiquinones predominantly. The plastidic… Expand
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References

SHOWING 1-10 OF 89 REFERENCES
Inhibition of the Non-Mevalonate 1-Deoxy-ᴅ-xylulose-5-phosphate Pathway of Plant Isoprenoid Biosynthesis by Fosmidomycin
Abstract Various bacterial and plastidic plant terpenoids are synthesized via the non-mevalonate1-deoxy-ᴅ-xylulose-5-phosphate (DOXP) pathway. The antibiotic and herbicidal compound fosmidomycin isExpand
Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate‐independent pathway
TLDR
The dichotomy in isoprenoid biosynthesis in higher plants allows a reasonable interpretation of previous odd and inconclusive results concerning the biosynthesis of chloroplast isopranoids, which so far had mainly been interpreted in the frame of models using compartmentation of the mevalonate pathway. Expand
Some new aspects of isoprenoid biosynthesis in plants—A review
  • T. Bach
  • Chemistry, Medicine
  • Lipids
  • 2006
TLDR
There are good arguments in favor of an exclusively cytoplasmic formation of isopentenyl pyrophosphate (IPP) via mevalonic acid via the socalled Rohmer pathway, but other studies and observations suggest an independent formation in plastids. Expand
Non-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors.
TLDR
The essential steps of the novel non-mevalonate pathway of isopentenyl diphosphate and isoprenoid biosynthesis in plants are described and all herbicides and inhibitors blocking this novel isopranoid pathway in plants have potential drugs against malaria and diseases caused by pathogenic bacteria. Expand
The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates.
TLDR
Although the mevalonate pathway had been considered for a long time as the unique source of biosynthetic isoprenoids, an alternative pathway has recently been discovered and the genes specifying these enzymes have been cloned from bacteria, plants and protozoa, opening the way to the identification of several novel pathway intermediates. Expand
Plant terpene biosynthesis. The biosynthesis of linalyl acetate in Mentha citrata
Abstract It is demonstrated that linalyl acetate is biosynthesised via the non-mevalonate (1-deoxyxylulose phosphate) terpene pathway in the plant Mentha citrata . The incorporation of isotopicallyExpand
The Non-Mevalonate Isoprenoid Biosynthesis of Plants as a Test System for New Herbicides and Drugs against Pathogenic Bacteria and the Malaria Parasite
TLDR
The antibiotic herbicide fosmidomycin specifically inhibited not only the DOXP reductoisomerase in plants, but also that in bacteria and in the parasite P. falciparum, and cures malaria-infected mice. Expand
The biosynthesis of C 5 –C 25 terpenoid compounds
TLDR
This review covers recently-published experimental information on the biosynthesis of terpenoids in the range C5–C25 and considers in turn hemiterpenoid, polyprenyl diphosphate synthases, monoterpenoids, sesquiter penoids, diterpenoids and sesterterpenoids. Expand
Deoxyxylulose phosphate pathway to terpenoids.
Recently, a mevalonate-independent pathway was discovered in bacteria and plants that leads to the formation of isopentenyl diphosphate and dimethylallyl diphosphate, the two basic precursors ofExpand
Isopentenyl diphosphate is the terminal product of the deoxyxylulose-5-phosphate pathway for terpenoid biosynthesis in plants
Abstract Secretory cells specialized for monoterpene biosynthesis via the deoxyxylulose-5-phosphate pathway for terpenoid biosynthesis were isolated from peppermint ( Mentha piperita ) leaves andExpand
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