An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders.

@article{Yang2015AnOO,
  title={An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders.},
  author={Yang Yang and Shuai Jiang and Juanjuan Yan and Yue Li and Zhenlong Xin and Yan Lin and Yan Qu},
  journal={Cytokine & growth factor reviews},
  year={2015},
  volume={26 1},
  pages={47-57}
}
Recently, growing evidence has demonstrated that nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal regulator of endogenous defense systems that function via the activation of a set of protective genes, and this is particularly clear in the central nervous system (CNS). Therefore, it is highly useful to summarize the current literature on the molecular mechanisms and role of Nrf2 in the CNS. In this review, we first briefly introduce the molecular features of Nrf2. We then discuss… CONTINUE READING
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