An overview of the intrathymic intricacies of T cell development.

Abstract

The generation of a functional and diverse repertoire of T cells occurs in the thymus from precursors arriving from the bone marrow. In this article, we introduce the various stages of mouse thymocyte development and highlight recent work using various in vivo, and, where appropriate, in vitro models of T cell development that led to discoveries in the regulation afforded by transcription factors and receptor-ligand signaling pathways in specifying, maintaining, and promoting the T cell lineage and the production of T cells. This review also discusses the role of the thymic microenvironment in providing a niche for the successful development of T cells. In particular, we focus on advances in Notch signaling and developments in Notch ligand interactions in this process.

DOI: 10.4049/jimmunol.1302259
0204060201520162017
Citations per Year

92 Citations

Semantic Scholar estimates that this publication has 92 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Shah2014AnOO, title={An overview of the intrathymic intricacies of T cell development.}, author={Divya K. Shah and Juan Carlos Z{\'u}{\~n}iga-Pfl{\"{u}cker}, journal={Journal of immunology}, year={2014}, volume={192 9}, pages={4017-23} }