An overview of the evolution of enterovirus 71 and its clinical and public health significance.

@article{McMinn2002AnOO,
  title={An overview of the evolution of enterovirus 71 and its clinical and public health significance.},
  author={Peter Charles McMinn},
  journal={FEMS microbiology reviews},
  year={2002},
  volume={26 1},
  pages={
          91-107
        }
}
Since its discovery in 1969, enterovirus 71 (EV71) has been recognised as a frequent cause of epidemics of hand-foot-and-mouth disease (HFMD) associated with severe neurological sequelae in a small proportion of cases. There has been a significant increase in EV71 epidemic activity throughout the Asia-Pacific region since 1997. Recent HFMD epidemics in this region have been associated with a severe form of brainstem encephalitis associated with pulmonary oedema and high case-fatality rates. The… CONTINUE READING
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