An overview of the computational analyses and discovery of transcription factor binding sites.

@article{Ladunga2010AnOO,
  title={An overview of the computational analyses and discovery of transcription factor binding sites.},
  author={Istv{\'a}n Ladunga},
  journal={Methods in molecular biology},
  year={2010},
  volume={674},
  pages={1-22}
}
Here we provide a pragmatic, high-level overview of the computational approaches and tools for the discovery of transcription factor binding sites. Unraveling transcription regulatory networks and their malfunctions such as cancer became feasible due to recent stellar progress in experimental techniques and computational analyses. While predictions of isolated sites still pose notorious challenges, cis-regulatory modules (clusters) of binding sites can now be identified with high accuracy… CONTINUE READING
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