An overview of sugar-modified oligonucleotides for antisense therapeutics.

@article{Prakash2011AnOO,
  title={An overview of sugar-modified oligonucleotides for antisense therapeutics.},
  author={Thazha P. Prakash},
  journal={Chemistry & biodiversity},
  year={2011},
  volume={8 9},
  pages={
          1616-41
        }
}
Among the multitude of chemical modifications that have been described over the past two decades, oligonucleotide analogs that are modified at the 2'-position of the furanose sugar have been especially useful for improving the drug-like properties of antisense oligonucleotides (ASOs). These modifications bias the sugar pucker towards the 3'-endo-conformation and improve ASO affinity for its biological target (i.e., mRNA). In addition, antisense drugs incorporating 2'-modified nucleotides… CONTINUE READING
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