An overview of nomegestrol acetate selective receptor binding and lack of estrogenic action on hormone-dependent cancer cells.

@article{ShieldsBotella2003AnOO,
  title={An overview of nomegestrol acetate selective receptor binding and lack of estrogenic action on hormone-dependent cancer cells.},
  author={Jacqueline Shields-Botella and Ir{\`e}ne Duc and Eric Duranti and Franca Puccio and P Bonnet and R{\'e}mi Delansorne and Jacques Paris},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2003},
  volume={87 2-3},
  pages={111-22}
}
The specific pharmacological profile of the 19-norprogestin nomegestrol acetate (NOMAC) is, at least in part, defined by its pattern of binding affinities to the different steroid hormone receptors. In the present study, its affinity to the progesterone receptor (PgR), the androgen receptor (AR) and the estrogen receptor (ER) was re-evaluated and compared to those obtained for progesterone (P) and several progestins. The characteristics of binding to the PgR in rat uterus were determined and Ki… CONTINUE READING

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