An overview of mortality and sequelae of preterm birth from infancy to adulthood

@article{Saigal2008AnOO,
  title={An overview of mortality and sequelae of preterm birth from infancy to adulthood},
  author={S. Saigal and L. Doyle},
  journal={The Lancet},
  year={2008},
  volume={371},
  pages={261-269}
}
Survival rates have greatly improved in recent years for infants of borderline viability; however, these infants remain at risk of developing a wide array of complications, not only in the neonatal unit, but also in the long term. Morbidity is inversely related to gestational age; however, there is no gestational age, including term, that is wholly exempt. Neurodevelopmental disabilities and recurrent health problems take a toll in early childhood. Subsequently hidden disabilities such as… Expand

Paper Mentions

Observational Clinical Trial
Prospective cohort study on pregnant women discharged from the hospital after their first episode of threatened preterm labor. Cervical length (CL) will be measured with transvaginal… Expand
ConditionsPreterm Labor With Preterm Delivery
InterventionOther
Interventional Clinical Trial
Available data suggest that low dose aspirin may be a safe, widely available and inexpensive intervention that may significantly reduce the risk of preterm birth. However, this… Expand
ConditionsPremature Birth
InterventionDrug
Long-term Outcomes of Very Preterm or Tiny Infants
TLDR
As mortality rates continue to fall, the focus for perinatal interventions must be strategies to reduce long-term morbidity, especially for cardiovascular, respiratory, and metabolic problems, and other lifestyle issues likely to be confronted by very preterm or tiny survivors. Expand
Very preterm children and the impact on neurodevelopmental outcomes
TLDR
A number of risk and protective factors that influence neurodevelopmental outcomes in very preterm individuals have been identified, providing opportunities for targeted therapies and early intervention to promote more optimal growth and development following very pre term birth. Expand
An overview of morbidity, mortality and long-term outcome of late preterm birth
TLDR
The growing number of late preterm neonates substantiates the importance to better understand and medically approach this special preterm subgroup, and a long-term evaluation, monitoring and follow-up ofLate preterm infants are needed to optimize neonatal care and improve human health status. Expand
Introduction: The Consequences of Being Born Very Early or Very Small
The rate of preterm birth (defined as deliveries that occur prior to 37 weeks’ gestational age) is increasing, and now represents 12–13% of all births in the United States (Goldenberg, Culhane, Iams,Expand
Preterm birth and neurodevelopmental outcome: a review
TLDR
The findings of the studies discussed in this article support the importance of early diagnosis in order to make decision about appropriate treatment of preterm infants, and the substantial stability of disability trends in this population was disappointing. Expand
Extremely Preterm Birth Outcome: A Review of Four Decades of Cognitive Research
TLDR
A review by the crucial variable of birth cohort year shows a changing developmental trajectory in which today’s extremely preterm survivor is likely to have fewer severe medical complications, better neurological outcomes, and fewer adverse cognitive late effects. Expand
Have outcomes following extremely preterm birth improved over time?
TLDR
There is no definite trend of improved neurodevelopment at school age for neurosensory, cognitive, academic achievement, motor or executive function with time, and Cerebral palsy rates, however, may be decreasing. Expand
Preterm birth and mortality in adulthood: a systematic review
  • C. Crump
  • Medicine
  • Journal of Perinatology
  • 2019
TLDR
The overall evidence indicates that premature birth during the past 50 years is associated with modestly increased mortality in early to mid-adulthood. Expand
Seminars in Fetal & Neonatal Medicine
TLDR
There is a need to understand their general growth and health outcomes not only in childhood, but also into adulthood, given the improving survival rates of extremely preterm infants. Expand
Neonatal and Perinatal Epidemiology
TLDR
There has been little improvement in the key drivers of infant mortality over this period – preterm birth and congenital malformations – attesting to the impact of newborn intensive care in reducing mortality in high risk newborns. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 166 REFERENCES
Survival and disability in babies less than 26 weeks' gestation
TLDR
In spite of improving survival rates, sensorineural disability rates remain higher than for non-preterm survivors, although there is no obvious demarcation that would preclude intensive care below a particular gestational age. Expand
Current Survival and Early Outcomes of Infants of Borderline Viability
TLDR
Because of the rapid progress in both obstetric and neonatal care and the changing outcomes, it is vital to continue to evaluate the recent survivors, and several recent publications address the early outcomes of regional cohorts of tiny infants based on reliable gestational age data. Expand
Increased survival and deteriorating developmental outcome in 23 to 25 week old gestation infants, 1990–4 compared with 1984–9
TLDR
The rise in disability with improved survival was not due to cerebral palsy; rather the main contributors were blindness due to retinopathy, myopia, and squint and the causes of these disabilities seem to be linked to high CRIB scores. Expand
Neonatal intensive care at borderline viability--is it worth it?
TLDR
Increased intensive care in the late 1990s for infants at the borderline of viability was associated with improved outcomes, at incremental costs that were not excessive compared with slightly more mature infants. Expand
Neurodevelopmental Outcomes of Infants Born Prematurely
  • G. Aylward
  • Psychology, Medicine
  • Journal of developmental and behavioral pediatrics : JDBP
  • 2005
TLDR
Suggestions for improved analyses and clarification of outcomes include use of cluster analysis, structural equation modeling, growth curve analysis, developmental epidemiologic approaches, and better control of background variables using risk indexes and factor scores. Expand
The contribution of mild and moderate preterm birth to infant mortality. Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System.
TLDR
Mild- and moderate-preterm birth infants are at high RR for death during infancy and are responsible for an important fraction of infant deaths. Expand
Improved Survival Rates With Increased Neurodevelopmental Disability for Extremely Low Birth Weight Infants in the 1990s
TLDR
The improved survival rates in the 1990s occurred with an increased risk of significant neurodevelopmental impairment, and prospective parents of extremely low birth weight infants should be advised of this substantial risk, to facilitate decision-making in the delivery room. Expand
Epidemiology and causes of preterm birth
TLDR
A short cervical length and a raised cervical-vaginal fetal fibronectin concentration are the strongest predictors of spontaneous preterm birth. Expand
The EPIBEL Study: Outcomes to Discharge From Hospital for Extremely Preterm Infants in Belgium
TLDR
If for the time being prolongation of pregnancy is unsuccessful, then outcome perspectives should be discussed and treatment options including nonintervention explicitly be made available to parents of infants of <26 weeks' gestation within the limits of medical feasibility and appropriateness. Expand
A national short-term follow-Up study of extremely low birth weight infants born in Finland in 1996-1997.
TLDR
The study shows that even with modern perinatal technology and care, intrauterine and early deaths of ELBW infants are common, and antenatal steroid treatment to mothers with threatening premature labor seemed to protect infants against these. Expand
...
1
2
3
4
5
...