An overview of matrix effects in liquid chromatography-mass spectrometry.


Matrix-dependent signal suppression or enhancement represents a major drawback in quantitative analysis with liquid chromatography coupled to atmospheric pressure ionization mass spectrometry (LC-API-MS). Because matrix effects (ME) might exert a detrimental impact on important method parameters (limit of detection, limit of quantification, linearity… (More)
DOI: 10.1002/mas.20298

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