An overview of inhibitors of Na(+)/H(+) exchanger.

  title={An overview of inhibitors of Na(+)/H(+) exchanger.},
  author={Bernard Masereel and Lionel Pochet and Didier Laeckmann},
  journal={European journal of medicinal chemistry},
  volume={38 6},
The Na(+)/H(+) exchanger (NHE) is involved in intracellular pH homeostasis of many mammalian cell types. To date seven NHE isoforms (NHE1-NHE7) have been identified. NHE1 is the most predominant isoform expressed in heart where it contributes to cardiomyocyte pH homeostasis. Although the NHE activation is essential for the restoration of physiological pH, hyperactivation of NHE1 during ischemia-reperfusion episodes disrupts the intracellular ion balance, leading to cardiac dysfunction and… CONTINUE READING