An overview of cell phenotypes in HCS: limitations and advantages

@article{Gasparri2009AnOO,
  title={An overview of cell phenotypes in HCS: limitations and advantages},
  author={Fabio Gasparri},
  journal={Expert Opinion on Drug Discovery},
  year={2009},
  volume={4},
  pages={643 - 657}
}
  • F. Gasparri
  • Published 21 May 2009
  • Biology
  • Expert Opinion on Drug Discovery
Background: High-content screening (HCS) defines a series of cell-based multiparametric approaches for analysis at the single-cell level. In recent years, HCS has been increasingly pursued in the drug discovery field, adding to the repertoire of assay type, or increasing throughput in applications such as compound screening and mechanism of action studies, as well as for target identification/validation (siRNA screening). Obviously, as cells represent the objects of high-content assays, the… 

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