• DOI:10.1159/000173504
Corpus ID: 3318576

An overall review on prenylamine mechanisms of action in experimental models of myocardial damage.

@article{Milei1982AnOR,
  title={An overall review on prenylamine mechanisms of action in experimental models of myocardial damage.},
  author={J. Milei and A. Vazquez and N. Bolomo},
  journal={Cardiology},
  year={1982},
  volume={69 4},
  pages={
          192-202
        }
}

• J. Milei, A. Vazquez, N. Bolomo
• Published 1982
• Medicine
• Cardiology

In this review we present the effects of a well-known antianginal drug, prenylamine (PNL), in experimental models of acute myocardial damage induced by a beta-agonistic drug, isoproterenol (ISP), in several trials conducted in our laboratory in both rats (n = 204) and monkeys (n = 26). PNL significantly inhibited ISP-induced lesions, protecting the majority of animals studied. Studies dealing with the site of action of the drug, such as 45Ca, 3H-PNL and 3H-ISP trials, showed a clear membrane… Expand