An overall review on prenylamine mechanisms of action in experimental models of myocardial damage.

  title={An overall review on prenylamine mechanisms of action in experimental models of myocardial damage.},
  author={Jos{\'e} Milei and Alberto Salas Vazquez and N J Bolomo},
  volume={69 4},
In this review we present the effects of a well-known antianginal drug, prenylamine (PNL), in experimental models of acute myocardial damage induced by a beta-agonistic drug, isoproterenol (ISP), in several trials conducted in our laboratory in both rats (n = 204) and monkeys (n = 26). PNL significantly inhibited ISP-induced lesions, protecting the majority of animals studied. Studies dealing with the site of action of the drug, such as 45Ca, 3H-PNL and 3H-ISP trials, showed a clear membrane… 
The Role of Prenylamine in the Prevention of Adriamycin-Induced Cardiotoxicity. A Review of Experimental and Clinical Findings
The mechanisms of adriamycin-related cardiotoxicity, the effects of prenylamine and the benefit from combined treatment are discussed.
The effects of prenylamine on single ventricular myocytes of guinea‐pig
It is concluded that prenylamine has a direct effect on cardiac calcium channels, not mediated by adrenoceptor activation, and was thus not due to indirect changes in endogenous catecholamine action.
Local Anesthetic Properties of Prenylamine
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Prenylamine block of Nav1.5 channel is mediated via a receptor distinct from that of local anesthetics.
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