An overall review on prenylamine mechanisms of action in experimental models of myocardial damage.

@article{Milei1982AnOR,
  title={An overall review on prenylamine mechanisms of action in experimental models of myocardial damage.},
  author={J. Milei and A. Vazquez and N. Bolomo},
  journal={Cardiology},
  year={1982},
  volume={69 4},
  pages={
          192-202
        }
}
In this review we present the effects of a well-known antianginal drug, prenylamine (PNL), in experimental models of acute myocardial damage induced by a beta-agonistic drug, isoproterenol (ISP), in several trials conducted in our laboratory in both rats (n = 204) and monkeys (n = 26). PNL significantly inhibited ISP-induced lesions, protecting the majority of animals studied. Studies dealing with the site of action of the drug, such as 45Ca, 3H-PNL and 3H-ISP trials, showed a clear membrane… Expand
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Amelioration of adriamycin-induced cardiotoxicity in rabbits by prenylamine and vitamins A and E.
TLDR
It is suggested that ADM leads to myocardial lipid peroxidation with membrane damage and to an increase in calcium permeability, the latter being counteracted by prenylamine. Expand
The Role of Prenylamine in the Prevention of Adriamycin-Induced Cardiotoxicity. A Review of Experimental and Clinical Findings
TLDR
The mechanisms of adriamycin-related cardiotoxicity, the effects of prenylamine and the benefit from combined treatment are discussed. Expand
The effects of prenylamine on single ventricular myocytes of guinea‐pig
TLDR
It is concluded that prenylamine has a direct effect on cardiac calcium channels, not mediated by adrenoceptor activation, and was thus not due to indirect changes in endogenous catecholamine action. Expand
Local Anesthetic Properties of Prenylamine
TLDR
The data presented here demonstrate that prenylamine possesses local anesthetic properties in vitro and elicits prolonged local anesthesia in vivo. Expand
Prenylamine block of Nav1.5 channel is mediated via a receptor distinct from that of local anesthetics.
We have shown previously that prenylamine, a calcium channel blocker, has potent local anesthetic activity in vivo and in vitro. We now characterize the tonic and use-dependent block of prenylamine… Expand