An outline of desensitization in pentameric ligand-gated ion channel receptors

@article{Keramidas2012AnOO,
  title={An outline of desensitization in pentameric ligand-gated ion channel receptors},
  author={Angelo Keramidas and Joseph W Lynch},
  journal={Cellular and Molecular Life Sciences},
  year={2012},
  volume={70},
  pages={1241-1253}
}
Pentameric ligand-gated ion channel (pLGIC) receptors exhibit desensitization, the progressive reduction in ionic flux in the prolonged presence of agonist. Despite its pathophysiological importance and the fact that it was first described over half a century ago, surprisingly little is known about the structural basis of desensitization in this receptor… CONTINUE READING