An outcrossed canine pedigree for linkage analysis of hip dysplasia.

@article{Todhunter1999AnOC,
  title={An outcrossed canine pedigree for linkage analysis of hip dysplasia.},
  author={Rory J. Todhunter and Gregory M. Acland and Michael Olivier and Alma Jo Williams and Margaret A Vernier-Singer and Nancy I. Burton-Wurster and James P. Farese and Yrj{\"o} Tapio Gr{\"o}hn and Robert Owen Gilbert and Nathan L. Dykes and George Lust},
  journal={The Journal of heredity},
  year={1999},
  volume={90 1},
  pages={83-92}
}
Canine hip dysplasia (CHD) is a prevalent, debilitating, polygenic disease characterized by hip subluxation and laxity which results in osteoarthritis. We are developing an informative pedigree for linkage analysis of CHD. The seven greyhound founders had excellent hip conformation with high dorsolateral subluxation scores (percentage of femoral head covered by the dorsal acetabulum in a weight-bearing position) of 66 +/- 4% (mean +/- SD averaged over both hips) and low hip distraction (laxity… CONTINUE READING