An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive study

@article{Lachance2010AnOO,
  title={An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive study},
  author={Daniel H. Lachance and Vanda A. Lennon and Sean J. Pittock and Jennifer A. Tracy and Karl N. Krecke and Kimberly K. Amrami and Eric M. Poeschla and Robert Michael Orenstein and Bernd W. Scheithauer and James Sejvar and Stacy M. Holzbauer and Aaron S DeVries and P. James B. Dyck},
  journal={The Lancet Neurology},
  year={2010},
  volume={9},
  pages={55-66}
}
Epidemiologic Investigation of Immune-Mediated Polyradiculoneuropathy among Abattoir Workers Exposed to Porcine Brain
TLDR
This novel polyradiculoneuropathy was associated with removing porcine brains with compressed air and an autoimmune mechanism is supported by higher levels of IFNγ in cases than in controls consistent with other immune mediated illnesses occurring in association with neural tissue exposure.
Auto‐immune polyradiculoneuropathy and a novel IgG biomarker in workers exposed to aerosolized porcine brain
  • J. Tracy, P. Dyck
  • Medicine, Biology
    Journal of the peripheral nervous system : JPNS
  • 2011
TLDR
It is postulate that this outbreak is an auto‐immune polyradiculoneuropathy triggered by occupational exposure to multiple aerosolized porcine neural tissue antigens that result in neural damage where the blood‐nerve barrier is the least robust.
Delayed onset of severe chronic pain in CASPR2 autoantibody–associated Morvan syndrome in a former UK swine abattoir worker
TLDR
The case of a 76-year-old, United Kingdom male diagnosed with contactin-associated protein 2 (CASPR2) autoantibody–associated Morvan syndrome, a rare neurological condition, highlights issues around the identification and treatment of rare patients with chronic pain who have voltage-gated potassium channel complexAutoantibodies and emphasizes the possibility that former swine abattoir workers might be at risk of developing neuropathic pain even years after their vocational exposure.
Immunotherapy-responsive pain in an abattoir worker with fluctuating potassium channel-complex IgG
TLDR
An early presenting case from this outbreak who was followed longitudinally with pain-predominant symptomatology, a newly recognized manifestation of voltage-gated potassium channel (VGKC)-complex autoimmunity is described.
Archeological neuroimmunology: resurrection of a pathogenic immune response from a historical case sheds light on human autoimmune encephalomyelitis and multiple sclerosis
TLDR
It is suggested that immunization with bovine brain tissue in humans may—in a small subset of patients—induce a disease with an intermediate clinical and pathological presentation between MS and MOG-antibody associated inflammatory demyelinating disease (MOGAD).
Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ?
TLDR
This study shows that auto-sensitization of humans with brain tissue can induce a disease, which closely reflects the pathology of MS, but that the mechanisms leading to demyelination and tissue injury differ from those, generally implicated in the pathophysiology of MS through studies in experimental autoimmune encephalomyelitis.
Neurologic autoimmunity: mechanisms revealed by animal models.
Neural antigen‐specific autoimmune disorders
TLDR
The focus of this review is the immunobiology, pathophysiology, and clinical spectrum of autoimmune neurological disorders accompanied by neural‐specific IgGs, which are frequently misdiagnosed as neurodegenerative.
CNS inflammation and neurodegeneration: sequelae of peripheral inoculation with spinal cord tissue in rat.
TLDR
The results of these experiments demonstrate that peripheral exposure to spinal cord antigens is associated with CNS-directed autoimmunity and inflammation in the brain and spinal cord as well as degeneration of CNS cells, memory impairment, and production of neurodegenerative proteins particularly when this exposure is repeated.
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