An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells.

@article{Chen2014AnOI,
  title={An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells.},
  author={Qing Chen and Peishun Shou and Liying Zhang and Chunliang Xu and Chunxing Zheng and Yanyan Han and Wenzhao Li and Yin Huang and Xiaoren Zhang and Changshun Shao and Arthur I. Roberts and Arnold B. Rabson and Guangwen Ren and Yanyun Zhang and Ying Wang and David T. Denhardt and Yufang Shi},
  journal={Stem cells},
  year={2014},
  volume={32 2},
  pages={327-37}
}
An imbalance between normal adipogenesis and osteogenesis by mesenchymal stem cells (MSCs) has been shown to be related to various human metabolic diseases, such as obesity and osteoporosis; however, the underlying mechanisms remain elusive. We found that the interaction between osteopontin (OPN), an arginine-glycine-aspartate-containing glycoprotein, and integrin αv/β1 plays a critical role in the lineage determination of MSCs. Although OPN is a well-established marker during osteogenesis, its… CONTINUE READING
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