An osmotic micro-pump integrated on a microfluidic chip for perfusion cell culture.

@article{Xu2010AnOM,
  title={An osmotic micro-pump integrated on a microfluidic chip for perfusion cell culture.},
  author={Zhang-Run Xu and Chun-guang Yang and Cui-Hong Liu and Zhe Zhou and Jin Fang and Jianhua Wang},
  journal={Talanta},
  year={2010},
  volume={80 3},
  pages={1088-93}
}
A novel microfluidic chip integrating an osmosis-based micro-pump was developed and used for perfusion cell culture. The micro-pump includes two sealed chambers, i.e., the inner osmotic reagent chamber and the outer water chamber, sandwiching a semi-permeable membrane. The water in the outer chamber was forced to flow through the membrane into the inner chamber via osmosis, facilitating continuous flow of fluidic zone in the channel. An average flow rate of 0.33microLmin(-1) was obtained within… CONTINUE READING
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