An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line

@article{Wang2005AnOM,
  title={An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line},
  author={Yuwei Wang and Hui Xue and J C Cutz and Jane Bayani and Nasrin R. Mawji and Wilfred G. Chen and Lester J Goetz and Simon W Hayward and Marianne D. Sadar and C. Blake Gilks and Peter W. Gout and Jeremy A Squire and Gerald R. Cunha and Yu-Zhuo Wang},
  journal={Laboratory Investigation},
  year={2005},
  volume={85},
  pages={1392-1404}
}
Metastasis is the major cause of prostate cancer deaths and there is a need for clinically relevant in vivo models allowing elucidation of molecular and cellular mechanisms underlying metastatic behavior. Here we describe the development of a new in vivo model system for metastatic prostate cancer. Pieces of prostate cancer tissue from a patient were grafted in testosterone-supplemented male NOD-SCID mice at the subrenal capsule graft site permitting high tumor take rates. After five serial… CONTINUE READING

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