An orthotopic floor-of-mouth model for locoregional growth and spread of human squamous cell carcinoma.

@article{Henson2007AnOF,
  title={An orthotopic floor-of-mouth model for locoregional growth and spread of human squamous cell carcinoma.},
  author={Bradley S Henson and Fu Li and Derek D. Coatney and Thomas E. Carey and Raj S. Mitra and Keith Lough Kirkwood and Nisha J D'silva},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  year={2007},
  volume={36 6},
  pages={363-70}
}
The molecular investigation of head and neck cancer targets requires the utilization and optimization of established animal models to characterize the effects of gene transcription and protein expression on invasion and metastasis. Floor-of-the-mouth murine models have been developed to study tumor growth, invasion, and metastasis of murine squamous cell carcinoma (SCC) cells in immunocompetent mice and invasion and metastasis of human SCC cells in nude mice. However, there are tumor cell lines… CONTINUE READING