An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors.

Abstract

The yeast two-hybrid screening was applied to cloning cDNAs of proteins that interact with peroxisome proliferator-activated receptor alpha (PPAR alpha). We obtained from a rat liver cDNA library a clone encoding a protein related to the ligand-binding domain of the members of nuclear hormone receptor superfamily, whereas apparently lacking the zinc-finger DNA-binding domain. This protein interacted with the activated forms of several nuclear receptors, and thus is a novel type of heterodimer-forming nuclear receptor.

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@article{Masuda1997AnON, title={An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors.}, author={Norikazu Masuda and Hiroaki Yasumo and Takehiro Tamura and Nobuto Hashiguchi and Takashi Furusawa and Taiji Tsukamoto and Hakaru Sadano and Takashi Osumi}, journal={Biochimica et biophysica acta}, year={1997}, volume={1350 1}, pages={27-32} }