An original approach to determining traces of tetracycline antibiotics in milk and eggs by solid-phase extraction and liquid chromatography/mass spectrometry.

@article{Bruno2002AnOA,
  title={An original approach to determining traces of tetracycline antibiotics in milk and eggs by solid-phase extraction and liquid chromatography/mass spectrometry.},
  author={Federica Bruno and Roberta Curini and Antonio Di Corcia and Manuela Nazzari and Marco Pallagrosi},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2002},
  volume={16 14},
  pages={1365-76}
}
An original and highly specific method able to identify and quantify traces of five tetracycline antibiotics (TCAs) in milk and eggs is presented. This method uses a single solid-phase extraction (SPE) cartridge for simultaneous extraction and purification of TCAs in the above matrices. After diluting 5 mL of intact whole milk or 2 g egg samples with Na(2)EDTA-containing water, samples are passed through a 0.5-g Carbograph 4 extraction cartridge. After analyte elution from the SPE cartridge, an… CONTINUE READING