An organocatalyst bound α-aminoalkyl radical intermediate for controlled aerobic oxidation of iminium ions.

@article{Motaleb2018AnOB,
  title={An organocatalyst bound $\alpha$-aminoalkyl radical intermediate for controlled aerobic oxidation of iminium ions.},
  author={Abdul Kadir Bin Motaleb and Asish Bera and Pradip Maity},
  journal={Organic \& biomolecular chemistry},
  year={2018},
  volume={16 28},
  pages={
          5081-5085
        }
}
A catalyst bound α-aminoalkyl radical intermediate from iminium is developed to control its formation and reactivity with aerobic oxygen. The influence of the catalyst was demonstrated via the ease of radical intermediate formation and its subsequent reactivity, including the first catalyst-controlled enantioselective aerobic oxidation with a chiral phosphite catalyst. 
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This review highlights recent achievements in catalytic enantioselective oxidations utilizing molecular oxygen as the sole oxidant, with focus on the mechanisms of dioxygen activation and chirogenesis in these transformations.
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Oxidation and Reduction
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