An organic acid-induced sigmoidal release system for oral controlled-release preparations. III. Elucidation of the anomalous drug release behavior through osmotic pumping mechanism

@inproceedings{Narisawa1997AnOA,
  title={An organic acid-induced sigmoidal release system for oral controlled-release preparations. III. Elucidation of the anomalous drug release behavior through osmotic pumping mechanism},
  author={Shinji Narisawa and Minako Nagata and Yoshiyuki Hirakawa and Masao Omiya Kobayashi and H. Yoshino},
  year={1997}
}
  • Shinji Narisawa, Minako Nagata, +2 authors H. Yoshino
  • Published 1997
  • Chemistry
  • To provide a reasonable explanation for the unique S-shaped drug release profile of sigmoidal release system (SRS), which is a newly developed multiparticulate oral time-controlled drug delivery system, the release mechanism was investigated. The dissolution studies were conducted for the theophylline-loaded SRS in water or in glucose aqueous solutions with different concentrations to vary osmotic pressure. In water, the initial lag time was extended with increasing coating level, whereas less… CONTINUE READING

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