An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis.

@article{Edling2002AnOC,
  title={An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis.},
  author={Andrea E. Edling and Swati Choksi and Ziwei Huang and Robert Korngold},
  journal={Journal of autoimmunity},
  year={2002},
  volume={18 2},
  pages={169-79}
}
CD4(+) T cells have an important role in mediating the pathogenesis of many human and experimental autoimmune diseases including experimental allergic encephalomyelitis (EAE), a demyelinating animal model for multiple sclerosis (MS). We applied a computer screening approach to select a small organic molecule, TJU103, that would specifically inhibit… CONTINUE READING