An oral formulation of nicotine for release and absorption in the colon: its development and pharmacokinetics.

@article{Green1999AnOF,
  title={An oral formulation of nicotine for release and absorption in the colon: its development and pharmacokinetics.},
  author={John T Green and Brian K. Evans and John Rhodes and Gareth A. O. Thomas and C Ranshaw and Colin Feyerabend and Michael A. H. Russell},
  journal={British journal of clinical pharmacology},
  year={1999},
  volume={48 4},
  pages={485-93}
}
AIMS Ulcerative colitis is predominantly a disease of nonsmokers and transdermal nicotine has therapeutic value in active disease; however side-effects are troublesome. The aim of this study was to develop an oral formulation of nicotine which would be slowly released in the colon over 6 h, and to examine its pharmacokinetic profile in 12 healthy volunteers, with measurements of serum nicotine and cotinine, its principal metabolite. METHODS Nicotine was combined with a polyacrylic carbomer… CONTINUE READING
5 Citations
22 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 22 references

A new presentation of lignocaine for bowel Hoschi R . How does cigarrette smoking delay solid and disease

  • NL Benowitz, F Kuyt, +7 authors MP Jones
  • Eur Hosp Pharm
  • 1998

How does cigarrette smoking delay solid and disease

  • R. Hoschi
  • Eur Hosp Pharm
  • 1998

Transdermal nicotine

  • RD Pullan, J Rhodes, S Ganesh
  • 1998

663–671. and cotinine in biological fluids

  • PJ Kahrilas, RR Gupta
  • J Pharm Pharmacol
  • 1997

A rapid gas - liquid ulcerative colitis unresponsive to first line therapy : a pilot chromatographic method for the determination of nicotine study

  • PJ Kahrilas, RR Gupta
  • Aliment Pharmacol Ther
  • 1997

; 104 : a 527

  • R Meier, C Beglinger, JP Dederding, H Porchet, L Sheiner, P Jacob
  • Gastroenterology
  • 1993

Stable isotope 31 Scott AM , Kellow JE , Shuter B , Nolan JM , Hoschl R , Jones studies of nicotine kinetics and bioavailability

  • NL Benowitz, P Jacob, C Denard, R Jenkins
  • Dig Dis Sci
  • 1992

A dose

  • RF Compton, WJ Sandborn, GM Lawson
  • Ther
  • 1991

Similar Papers

Loading similar papers…