An oral developmental neurotoxicity study of decabromodiphenyl ether (DecaBDE) in rats.

@article{Biesemeier2011AnOD,
  title={An oral developmental neurotoxicity study of decabromodiphenyl ether (DecaBDE) in rats.},
  author={John A. Biesemeier and Melissa J. Beck and Hanna Silberberg and Nicole R. Myers and John M Ariano and Ann Radovsky and Les Freshwater and Daniel W Sved and Sylvia Jacobi and Donald G. Stump and Marcia L. Hardy and Todd Stedeford},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2011},
  volume={92 1},
  pages={
          17-35
        }
}
BACKGROUND Decabromodiphenyl ether (DecaBDE; CASRN 1163-19-5) is a flame retardant used in a variety of manufactured products. A single oral dose of 20.1 mg/kg administered to mice on postnatal day 3 has been reported to alter motor activity at 2, 4, and 6 months of age. METHODS To further evaluate these results, a developmental neurotoxicity study was conducted in the most commonly used species for studies of this type, the rat, according to international validated testing guidelines and… CONTINUE READING