An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study.

@article{Hirt2008AnOI,
  title={An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study.},
  author={D{\'e}borah Hirt and Bart van Overmeire and J. -M. Treluyer and J -P Langhendries and Arnaud Marguglio and Mark J Eisinger and Paul Schepens and Sa{\"i}k Urien},
  journal={British journal of clinical pharmacology},
  year={2008},
  volume={65 5},
  pages={629-36}
}
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Ibuprofen is a nonsteroidal anti-inflammatory agent that induces closure of the patent ductus arteriosus in neonates. Few studies of ibuprofen pharmacokinetics have been performed and were limited to small groups of preterm infants, showing a large intersubject variability and an increase in clearance with either postnatal or gestational age. WHAT THIS STUDY ADDS A population pharmacokinetic study was performed on 66 neonates to characterize the… CONTINUE READING
35 Citations
12 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 12 references

A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus

  • B Van Overmeire, K Smets, +4 authors JP. Langhendries
  • N Engl J Med
  • 2000

NONMEM User’s Guide; NONMEM Project Group

  • SL Beal, LB Sheiner
  • San Francisco: University of California,
  • 1998

Similar Papers

Loading similar papers…