An optimized CD8+ T-cell response controls productive and latent gammaherpesvirus infection.

@article{Braaten2005AnOC,
  title={An optimized CD8+ T-cell response controls productive and latent gammaherpesvirus infection.},
  author={Douglas C. Braaten and Rebecca L Sparks-Thissen and Scott A. Kreher and Samuel H Speck and Herbert W Virgin},
  journal={Journal of virology},
  year={2005},
  volume={79 4},
  pages={2573-83}
}
Strategies to prime CD8(+) T cells against Murine gammaherpesvirus 68 (gammaHV68; MHV68) latency have, to date, resulted in only limited effects. While early forms of latency (<21 days) were significantly reduced, effects were not seen at later times, indicating loss of control by the primed CD8(+) T cells. In the present study, we evaluated CD8(+) T cells in an optimized system, consisting of OTI T-cell-receptor (TCR) transgenic mice, which generate clonal CD8(+) T cells specific for K(b… CONTINUE READING
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