An opioid benzodiazepine

@article{Rmer1982AnOB,
  title={An opioid benzodiazepine},
  author={D. R{\"o}mer and H. B{\"u}scher and R. C. Hill and R. Maurer and T. Petcher and H. Zeugner and W. Benson and E. Finner and W. Milkowski and P. Thies},
  journal={Nature},
  year={1982},
  volume={298},
  pages={759-760}
}
Although the benzodiazepines have been extensively investigated since their discovery about 20 years ago1, only recently have antagonists of the classical actions of benzodiazepines been described2. We have now discovered a class of benzodiazepines which have lost all affinity for benzodiazepine binding sites but which have moderate to high affinity for opiate receptors. Depending on the substituents introduced, it is possible to obtain compounds with selective actions on μ, δ and… Expand
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