An open study of oral flesinoxan, a 5‐HT1A receptor agonist, in treatment‐resistant depression

@article{Grof1993AnOS,
  title={An open study of oral flesinoxan, a 5‐HT1A receptor agonist, in treatment‐resistant depression},
  author={Paul Grof and Russell T. Joffe and S. Kennedy and Emmanuel Persad and J Syrotiuk and Dawn Bradford},
  journal={International Clinical Psychopharmacology},
  year={1993},
  volume={8},
  pages={167–172}
}
Flesinoxan, a full 5-HT1A, receptor agonist, was administered (4–8 mg) to treatment-resistant depressed patients in an open study. Safety and tolerance of the substance appeared satisfactory. Headache, dizziness and nausea were the most frequently reported side effects. The observations suggested that flesinoxan is an antidepressant agent and that it may be of particular value in some difficult, treatment-resistant depressions. Based on these observations, a double-blind, placebo-controlled… Expand
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