An open-label study of repeated use of diazepam rectal gel (Diastat) for episodes of acute breakthrough seizures and clusters: safety, efficacy, and tolerance. North American Diastat Group.

@article{Mitchell1999AnOS,
  title={An open-label study of repeated use of diazepam rectal gel (Diastat) for episodes of acute breakthrough seizures and clusters: safety, efficacy, and tolerance. North American Diastat Group.},
  author={Wendy G Mitchell and Joan A Conry and Patricia K. Crumrine and Robert L Kriel and James J Cereghino and Leslie Groves and William E Rosenfeld},
  journal={Epilepsia},
  year={1999},
  volume={40 11},
  pages={1610-7}
}
PURPOSE To assess safety of diazepam rectal gel (DZPRG) for control of acute seizures in epilepsy patients and to evaluate tolerance with repeated use of DZPRG at intervals of > or =5 days. METHODS Subjects were persons with epilepsy, age 2 years or older, with seizure clusters or prolonged seizures. Onset of a treatable episode was defined; caregivers were trained to administer DZPRG and to monitor respiration, seizures, and adverse effects (AEs). DZPRG was dispensed in a single-use… CONTINUE READING