An open-label phase 1 clinical trial of the anti-α4β7 monoclonal antibody vedolizumab in HIV-infected individuals

@article{Sneller2019AnOP,
  title={An open-label phase 1 clinical trial of the anti-$\alpha$4$\beta$7 monoclonal antibody vedolizumab in HIV-infected individuals},
  author={Michael C. Sneller and Katherine E. Clarridge and Catherine A. Seamon and Victoria Shi and Marek Dominick Zorawski and Jesse S. Justement and Jana Blazkova and Erin D Huiting and Michael A. Proschan and Jorge Rodrigo Mora and Michael Shetzline and Susan Moir and Henry Clifford Lane and Tae-Wook Chun and Anthony S. Fauci},
  journal={Science Translational Medicine},
  year={2019},
  volume={11}
}
Infusions of anti-α4β7 monoclonal antibody did not affect plasma viral rebound in HIV-infected individuals who stopped antiretroviral drug therapy. Targeting α4β7 in HIV Nonhuman primate models can be useful in the development of new approaches to treating HIV infection. Sneller et al. conducted a human therapeutic trial based on promising results of a single nonhuman primate study in which treatment with an anti-integrin monoclonal antibody led to sustained suppression of SIV plasma viremia… Expand
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