• Corpus ID: 231847017

An open debate on SARS-CoV-2's proximal origin is long overdue

  title={An open debate on SARS-CoV-2's proximal origin is long overdue},
  author={Rossana Segreto and Yuri Deigin and K. McCairn and Alejandro Sousa and Dan Sirotkin and Karl Sirotkin and Jonathan J. Couey and Adrian Jones and Daoyu Zhang Department of Microbiology and University of Innsbruck and Austria and Youthereum Genetics Inc. and Toronto and Ontario and Canada. and Synaptek - Deep Learning Solutions and G{\^i}fu and Japan. and R Monforte and Lugo and Spain. and University of Santiago de Compostela and Karl Sirotkin Llc and Lake Mary and FL 32746 and Usa and University of Pittsburgh and School of Clinical Medicine and Independent Researcher and Independent Researcher},
There is a near consensus view that SARS-CoV-2 has a natural zoonotic origin;however, several characteristics of SARS-CoV-2 taken together are not easily explained by a natural zoonotic origin hypothesis. These include: a low rate of evolution in the early phase of transmission;the lack of evidence of recombination events;a high pre-existing binding to human ACE2;a novel furin cleavage site insert;a flat glycan binding domain of the spike protein which conflicts with host evasion survival… 

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