An open, randomized, controlled trial of penicillin, doxycycline, and cefotaxime for patients with severe leptospirosis.

@article{Suputtamongkol2004AnOR,
  title={An open, randomized, controlled trial of penicillin, doxycycline, and cefotaxime for patients with severe leptospirosis.},
  author={Yupin Suputtamongkol and Kanigar Niwattayakul and Chuanpit Suttinont and Kitti Losuwanaluk and Roongroeng Limpaiboon and Wirongrong Chierakul and Vanaporn Wuthiekanun and Surapee Triengrim and Mongkol Chenchittikul and Nicholas J White},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2004},
  volume={39 10},
  pages={1417-24}
}
BACKGROUND Leptospirosis is an important cause of fever in the rural tropics. Since 1996, there has been a marked increase in the incidence of leptospirosis in northeastern Thailand. Although leptospirosis generally is susceptible to antibiotics, there is no consensus regarding the optimal treatment for severe leptospirosis. METHODS An open-label, randomized comparison of parenteral cefotaxime, penicillin G sodium (hereafter known as "penicillin G"), and doxycycline for the treatment of… CONTINUE READING

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Leptospirosis: a zoonotic disease of global concern

  • AR Bharti, JE Nally, JN Ricaldi
  • Lancet Infect Dis
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