An oncogenic hub: beta-catenin as a molecular target for cancer therapeutics.

@article{Takemaru2008AnOH,
  title={An oncogenic hub: beta-catenin as a molecular target for cancer therapeutics.},
  author={Ken-Ichi Takemaru and Masao Ohmitsu and F Li},
  journal={Handbook of experimental pharmacology},
  year={2008},
  volume={186},
  pages={261-84}
}
The Wnt/beta-catenin signaling pathway plays diverse roles in embryonic development and in maintenance of organs and tissues in adults. Activation of this signaling cascade inhibits degradation of the pivotal component beta-catenin, which in turn stimulates transcription of downstream target genes. Over the past two decades, intensive worldwide investigations have yielded considerable progress toward understanding the cellular and molecular mechanisms of Wnt signaling and its involvement in the… CONTINUE READING

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