An oncogenetic tree model in gastrointestinal stromal tumours (GISTs) identifies different pathways of cytogenetic evolution with prognostic implications.

@article{Gunawan2007AnOT,
  title={An oncogenetic tree model in gastrointestinal stromal tumours (GISTs) identifies different pathways of cytogenetic evolution with prognostic implications.},
  author={Bastian Gunawan and Anja von Heydebreck and Birgitta Sander and H-J Schulten and Florian Haller and Claus Oliver Langer and Thomas Armbrust and Magdolna Bollmann and Slavko Ga{\vs}parov and Dra{\vz}en Kova{\vc} and L{\'a}szl{\'o} F{\"u}zesi},
  journal={The Journal of pathology},
  year={2007},
  volume={211 4},
  pages={
          463-70
        }
}
To model the cytogenetic evolution in gastrointestinal stromal tumour (GIST), an oncogenetic tree model was reconstructed using comparative genomic hybridization data from 203 primary GISTs (116 gastric and 87 intestinal GISTs, including 151 newly analysed cases), with follow-up available in 173 cases (mean 40 months; maximum 133 months). The oncogenetic tree model identified three major cytogenetic pathways: one initiated by -14q, one by -1p, and another by -22q. The -14q pathway mainly… CONTINUE READING
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