An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB

@article{Min2010AnOS,
  title={An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB},
  author={Junxia Min and Alexander Zaslavsky and Giuseppe Fedele and Sara Koenig McLaughlin and Elizabeth E. Reczek and Thomas De Raedt and Isil Guney and David E. Strochlic and Laura E Macconaill and Rameen Beroukhim and Roderick Terry Bronson and Sandra W. Ryeom and William C. Hahn and Massimo F. Loda and Karen Cichowski},
  journal={Nature Medicine},
  year={2010},
  volume={16},
  pages={286-294}
}
Metastasis is responsible for the majority of prostate cancer–related deaths; however, little is known about the molecular mechanisms that underlie this process. Here we identify an oncogene–tumor suppressor cascade that promotes prostate cancer growth and metastasis by coordinately activating the small GTPase Ras and nuclear factor-κB (NF-κB). Specifically, we show that loss of the Ras GTPase-activating protein (RasGAP) gene DAB2IP induces metastatic prostate cancer in an orthotopic mouse… CONTINUE READING
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