An oligodeoxynucleotide with CCT repeats restrains CpG ODN-induced TLR9 trafficking.

@article{Zhang2014AnOW,
  title={An oligodeoxynucleotide with CCT repeats restrains CpG ODN-induced TLR9 trafficking.},
  author={Xiaoling Zhang and Wei Sun and Xiuli Wu and Hua Wang and Youyou Yan and Sheng Jie Guo and Dandan Song and Hainan Li and Shuang Gao and Luowei Wang and Yongli Yu and Liying Wang},
  journal={Current pharmaceutical biotechnology},
  year={2014},
  volume={15 9},
  pages={780-9}
}
Toll-like receptor 9 (TLR9) can sense pathogen DNA and CpG ODN or even self-DNA by trafficking assisted by Unc93B1, an endoplasmic reticulum (ER) transmembrane protein, from ER to endolysosomes or cell surface. In previous study, we found that an oligodeoxynucleotide with CCT repeats (SAT05f) could selectively inhibit TLR7/9 activation. However, the mechanism for the inhibitory activity of SAT05f is still unknown. In present research, it was found that SAT05f could inhibit CpG ODN-induced the… CONTINUE READING
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