An oldie but a goodie - cell wall biosynthesis as antibiotic target pathway.

  title={An oldie but a goodie - cell wall biosynthesis as antibiotic target pathway.},
  author={Tanja Schneider and H. -G. Sahl},
  journal={International journal of medical microbiology : IJMM},
  volume={300 2-3},
Bacterial cell wall biosynthesis represents the target pathway for penicillin, the first antibiotic that was clinically applied on a large scale. Penicillin, by means of its beta-lactam ring, inhibits a number of enzymes which participate in inserting monomeric cell wall building blocks into the cell wall polymer and which have been termed penicillin-binding proteins (PBPs). Ever since the introduction of penicillin, hundreds of beta-lactam antibiotics have been developed and details of their… CONTINUE READING


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