An oldie but a goodie - cell wall biosynthesis as antibiotic target pathway.

@article{Schneider2010AnOB,
  title={An oldie but a goodie - cell wall biosynthesis as antibiotic target pathway.},
  author={Tanja Schneider and H. -G. Sahl},
  journal={International journal of medical microbiology : IJMM},
  year={2010},
  volume={300 2-3},
  pages={161-9}
}
Bacterial cell wall biosynthesis represents the target pathway for penicillin, the first antibiotic that was clinically applied on a large scale. Penicillin, by means of its beta-lactam ring, inhibits a number of enzymes which participate in inserting monomeric cell wall building blocks into the cell wall polymer and which have been termed penicillin-binding proteins (PBPs). Ever since the introduction of penicillin, hundreds of beta-lactam antibiotics have been developed and details of their… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

LipidII: Just Another Brick in the Wall?

View 4 Excerpts
Highly Influenced

Peptide antimicrobials: cell wall as a bacterial target.

Annals of the New York Academy of Sciences • 2013
View 5 Excerpts
Highly Influenced

A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance.

Proceedings of the National Academy of Sciences of the United States of America • 2016

References

Publications referenced by this paper.
Showing 1-10 of 62 references

The emergence of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases • 2006
View 3 Excerpts
Highly Influenced

Addressing the challenge of extended-spectrum beta-lactamases.

Current opinion in investigational drugs • 2009
View 2 Excerpts

AmpC beta-lactamases.

Clinical microbiology reviews • 2009
View 1 Excerpt

Similar Papers

Loading similar papers…