An old kinase on a new path: Raf and apoptosis

  title={An old kinase on a new path: Raf and apoptosis},
  author={Manuela Baccarini},
  journal={Cell Death and Differentiation},
The cytosolic serine/threonine Raf kinases play a central role in evolutionary conserved signal transduction pathways. An impressive number of publications implicates these enzymes in a variety of biological processes, most prominently in regulated and deregulated proliferation. Because of this, they are considered attractive therapeutic targets. Gene ablation experiments have now revealed that in the context of the mouse embryo Raf-1 and B-Raf play essential anti-apoptotic roles that cannot be… CONTINUE READING

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