An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease.

@article{Klings2014AnOA,
  title={An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease.},
  author={E. S. Klings and Roberto F. Machado and Robyn J. Barst and Claudia R. Morris and Kamal K. Mubarak and Victor R Gordeuk and Gregory J. Kato and Kenneth I Ataga and John Simon Russell Gibbs and Oswaldo Revelo Castro and Erika S Berman Rosenzweig and Namita Sood and Lewis Hsu and Kevin C Wilson and Marilyn J Telen and Laura M Decastro and Lakshmanan Krishnamurti and Martin H Steinberg and David B. Badesch and Mark T Gladwin},
  journal={American journal of respiratory and critical care medicine},
  year={2014},
  volume={189 6},
  pages={727-40}
}
BACKGROUND In adults with sickle cell disease (SCD), an increased tricuspid regurgitant velocity (TRV) measured by Doppler echocardiography, an increased serum N-terminal pro-brain natriuretic peptide (NT-pro-BNP) level, and pulmonary hypertension (PH) diagnosed by right heart catheterization (RHC) are independent risk factors for mortality. METHODS A multidisciplinary committee was formed by clinician-investigators experienced in the management of patients with PH and/or SCD. Clinically… CONTINUE READING

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