An official ATS statement: hepatotoxicity of antituberculosis therapy.

@article{Saukkonen2006AnOA,
  title={An official ATS statement: hepatotoxicity of antituberculosis therapy.},
  author={Jussi J Saukkonen and D. L. Cohn and Robert M. Jasmer and Steven Schenker and John A. Jereb and Charles M. Nolan and Charles A Peloquin and Fred M. Gordin and David Nunes and Dorothy B Strader and John Bernardo and Raman Venkataramanan and Timothy R. Sterling},
  journal={American journal of respiratory and critical care medicine},
  year={2006},
  volume={174 8},
  pages={
          935-52
        }
}
  • Jussi J Saukkonen, D. L. Cohn, +10 authors Timothy R. Sterling
  • Published 2006
  • Medicine
  • American journal of respiratory and critical care medicine
  • Drug-induced liver injury (DILI) is a problem of increasing significance, but has been a long-standing concern in the treatment of tuberculosis (TB) infection. The liver has a central role in drug metabolism and detoxification, and is consequently vulnerable to injury. The pathogenesis and types of DILI are presented, ranging from hepatic adaptation to hepatocellular injury. Knowledge of the metabolism of anti-TB medications and of the mechanisms of TB DILI is incomplete. Understanding of TB… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 172 REFERENCES

    Antituberculosis drug-induced hepatotoxicity. The role of hepatitis C virus and the human immunodeficiency virus.

    VIEW 3 EXCERPTS
    HIGHLY INFLUENTIAL

    Liver injury during antituberculosis treatment: an 11-year study.

    VIEW 4 EXCERPTS
    HIGHLY INFLUENTIAL