An observational method for quantifying the behavioural effects of dopamine agonists: Contrasting effects of d-Amphetamine and apomorphine

@article{Fray1980AnOM,
  title={An observational method for quantifying the behavioural effects of dopamine agonists: Contrasting effects of d-Amphetamine and apomorphine},
  author={P. J. Fray and Barbara J. Sahakian and Trevor W. Robbins and George F. Koob and Susan D. Iversen},
  journal={Psychopharmacology},
  year={1980},
  volume={69},
  pages={253-259}
}
A novel means of measuring and analysing behavioural effects of dopamine agonists is described and illustrated by a comparison of the effects of d-amphetamine and apomorphine in the rat. d-Amphetamine (0–15 mg/kg IP) produced significant dose- and time-dependent changes in responses such as locomotion, rearing and sniffing, but not in licking or gnawing. In contrast, apomorphine (0–5 mg/kg SC) produced significant increases in licking and gnawing, as well as in locomotion and sniffing, but no… CONTINUE READING
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